More Drivers than We Thought for Fly Circadian Rhythm

Flies can’t keep track of time if their many internal clocks are wildly out of synch, and, according to a new study, keeping them in synch requires more neuron networks than previously thought. 

Read more about this research from the 28 March issue of Science here.

[Image courtesy of Orie Shafer. Please click here for more information.]

© 2014 American Association for the Advancement of Science. All Rights Reserved.

More Drivers than We Thought for Fly Circadian Rhythm

Flies can’t keep track of time if their many internal clocks are wildly out of synch, and, according to a new study, keeping them in synch requires more neuron networks than previously thought.

Read more about this research from the 28 March issue of Science here.

[Image courtesy of Orie Shafer. Please click here for more information.]

© 2014 American Association for the Advancement of Science. All Rights Reserved.

Seeing the Classic Cancer Drug Paclitaxel in a New Light

A new study radically changes our understanding of how one of the most common cancer drugs works. Knowing the correct mode of action of the drug, called paclitaxel, could help improve prediction of which patients are likely to respond to it, and may also help refine the design of next-generation cancer drugs.

Read more about this research from the 26 March issue of Science Translational Medicine here.

[mage courtesy of Lauren M. Zasadil and Beth A. Weaver. Please click here for more information.]

© 2014 American Association for the Advancement of Science. All Rights Reserved.

Seeing the Classic Cancer Drug Paclitaxel in a New Light

A new study radically changes our understanding of how one of the most common cancer drugs works. Knowing the correct mode of action of the drug, called paclitaxel, could help improve prediction of which patients are likely to respond to it, and may also help refine the design of next-generation cancer drugs.

Read more about this research from the 26 March issue of Science Translational Medicine here.

[mage courtesy of Lauren M. Zasadil and Beth A. Weaver. Please click here for more information.]

© 2014 American Association for the Advancement of Science. All Rights Reserved.

“Mount Everest” of Synthetic Biology: First Eukaryotic Chromosome

For the first time, researchers have synthesized a eukaryotic chromosome, a new study reports. The chromosome was from one of the best-studied organisms on the planet, baker’s yeast, or Saccharomyces cerevisiae. Yeast is already used to make beer, biofuel and medicine, but once equipped with a full set of synthetic and changeable chromosomes like the one designed here, this single-celled organism could produce better versions of these important commodities, including new antibiotics or more environmentally friendly biofuels.

In this video courtesy of New York University Langone Medical Center, Dr. Jef Boeke discusses the research.

Read more about this research from the 28 March issue of Science here.

© 2014 American Association for the Advancement of Science. All Rights Reserved.

amnhnyc:

Recognize the Gila monster? The dramatic pink, orange, black, and yellow markings on this lizard’s skin may serve as a warning to predators to stay away or risk a painful bite. But the powerful venom of the Gila monster, which is featured as one of the live species in The Power of Poison, has medicinal capabilities as well: one of its components has been used to develop a diabetes drug.Learn more about the Gila monster.

amnhnyc:

Recognize the Gila monster? 
The dramatic pink, orange, black, and yellow markings on this lizard’s skin may serve as a warning to predators to stay away or risk a painful bite. But the powerful venom of the Gila monster, which is featured as one of the live species in The Power of Poison, has medicinal capabilities as well: one of its components has been used to develop a diabetes drug.
Learn more about the Gila monster.

Shocking Black Hole in M83

Composite image from NASA’s Hubble Space Telescope of the spiral galaxy M83 (diameter ~70% that of the Milky Way). Embedded near the center of this image is a stellar-mass black hole that bombards its surroundings with kinetic energy through hugely powerful jets. See pages 1318 and 1330.

Image: NASA, ESA, and the Hubble Heritage Team (STScI/AURA); W. P. Blair (STScI/JHU)

Anyone wishing to use the cover of Science must contact AAAS to request permission to do so.

© 2014 American Association for the Advancement of Science. All Rights Reserved.

latimes:

The sun emitted a mid-level solar flare on April 2, and NASA captured it in this video, which, the agency says, “shows the flare in a blend of two wavelengths of extreme ultraviolet light: 171 Angstroms and 304 Angstroms, colorized in yellow and red, respectively.”

The Proteins That Put Plants on Land?

Before Earth’s early plant life could make the transition from water to land, such botanical pioneers had to evolve specialized cells for conducting water — and a particular group of proteins, known as NAC transcription factors, likely played a significant role in that development, according to a new study. 

Read more about this research from the 21 March issue of Science Express here.

[Image courtesy of Mayuko Sato, Mayumi Wakazaki, and Kiminori Toyooka. Please click here for more information.]

© 2014 American Association for the Advancement of Science. All Rights Reserved.

The Proteins That Put Plants on Land?

Before Earth’s early plant life could make the transition from water to land, such botanical pioneers had to evolve specialized cells for conducting water — and a particular group of proteins, known as NAC transcription factors, likely played a significant role in that development, according to a new study.

Read more about this research from the 21 March issue of Science Express here.

[Image courtesy of Mayuko Sato, Mayumi Wakazaki, and Kiminori Toyooka. Please click here for more information.]

© 2014 American Association for the Advancement of Science. All Rights Reserved.

Unraveling the Antibody Mystery in HIV Vaccine Trials

An antibody of the IgG3 type, an antibody subclass known to protect against malaria and other infectious diseases, may be responsible for the variable immune response triggered by two different HIV vaccines in recent clinical trials, two new studies report. The findings could help scientists boost particular immune responses in future vaccine studies, with the aim of getting closer to an HIV vaccine that’s effective and long-lasting. 

Read more about this research from the 19 March issue of Science Translational Medicine here.

[Image courtesy of V. Altounian/Science Translational Medicine]

© 2014 American Association for the Advancement of Science. All Rights Reserved.

Unraveling the Antibody Mystery in HIV Vaccine Trials

An antibody of the IgG3 type, an antibody subclass known to protect against malaria and other infectious diseases, may be responsible for the variable immune response triggered by two different HIV vaccines in recent clinical trials, two new studies report. The findings could help scientists boost particular immune responses in future vaccine studies, with the aim of getting closer to an HIV vaccine that’s effective and long-lasting.

Read more about this research from the 19 March issue of Science Translational Medicine here.

[Image courtesy of V. Altounian/Science Translational Medicine]

© 2014 American Association for the Advancement of Science. All Rights Reserved.

Chromosomal Clues to Cancer Survival

Molecules called cytokines that function in cell signaling and are found on chromosomes could offer clues to the survival of cancer patients, a new study reports. The findings hint that therapies designed to boost or mimic IL-15 and increase the proliferation of T cells may be effective for treating cancer.

Read more about this research from the 19 March issue of Science Translational Medicine here.

[Image courtesy of Jerome Galon, INSERM, Paris, France. Please click here for more information.]

© 2014 American Association for the Advancement of Science. All Rights Reserved.

Chromosomal Clues to Cancer Survival

Molecules called cytokines that function in cell signaling and are found on chromosomes could offer clues to the survival of cancer patients, a new study reports. The findings hint that therapies designed to boost or mimic IL-15 and increase the proliferation of T cells may be effective for treating cancer.

Read more about this research from the 19 March issue of Science Translational Medicine here.

[Image courtesy of Jerome Galon, INSERM, Paris, France. Please click here for more information.]

© 2014 American Association for the Advancement of Science. All Rights Reserved.

Iron-clad Insights into Useful Dust

Scientists have better insight into what caused changes in atmospheric carbon dioxide concentrations across glacial cycles, a new study reports.

Read more about this research from the 21 March issue of Science here.

[Image courtesy of William M. Putman and Arlindo M. da Silva (NASA/Goddard Space Flight Center). Please click here for more information.]

© 2014 American Association for the Advancement of Science. All Rights Reserved.

Iron-clad Insights into Useful Dust

Scientists have better insight into what caused changes in atmospheric carbon dioxide concentrations across glacial cycles, a new study reports.

Read more about this research from the 21 March issue of Science here.

[Image courtesy of William M. Putman and Arlindo M. da Silva (NASA/Goddard Space Flight Center). Please click here for more information.]

© 2014 American Association for the Advancement of Science. All Rights Reserved.

© 2014 American Association for the Advancement of Science. All Rights Reserved.